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Mechanism of NPWT action

Mechanism of VivereX® action

How VivereX® influences the wound pathophysiological environment?

VivereX® mechanism of action may be divided in two groups, primary and secondary mechanisms:
Primary mechanisms

  1. macrodeformation
  2. microdeformation
  3. fluid removal
  4. stabilization of the wound environment

Secondary effects
involved in mechano-transduction pathways that alter the biology of wound healing

  1. angiogenesis
  2. neurogenesis
  3. granulation tissue formation
  4. cellular proliferation, differentiation and migration

Macrodeformation refers to induced wound shrinkage caused by collapse of the pores and centripetal forces exerted onto the wound surface by the foam.

Microdeformation Refers to the undulated wound surface induced by the porous interface material when exposed to suction.

Applying a vacuum to this surface results in fluid removal from many wounds including the extracellular space, particularly in fasciotomy wounds or in open abdominal wounds. Fluid removal likely reduces compression of the microvasculature, thus optimizes tissue perfusion potentially allowing increased blood flow to the wound bed.

The dressing’s material inclusive semi-occlusive drape act as thermal insulators to maintain wound warmth.